Hypoalbuminemia and Pharmacokinetics: When the Misunderstanding of a Fundamental Concept Leads to Repeated Errors over Decades

Autor: Peggy Gandia, Sarah Decheiver, Manon Picard, Romain Guilhaumou, Sarah Baklouti, Didier Concordet
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Antibiotics, Vol 12, Iss 3, p 515 (2023)
Druh dokumentu: article
ISSN: 2079-6382
DOI: 10.3390/antibiotics12030515
Popis: Surprisingly, misinterpretation of the influence of hypoalbuminemia on pharmacokinetics and the clinical effects of drugs seems to be a current problem, even though hypoalbuminemia has no impact on the pharmacologically active exposure. Exceptions to this fact are highly protein-bound anaesthetics with high elimination capacity (i.e.,
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