Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

Autor: Néstor Saiz, Kiah M. Williams, Venkatraman E. Seshan, Anna-Katerina Hadjantonakis
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13463
Popis: Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of its size.
Databáze: Directory of Open Access Journals