Comparison of Intratesticular Testosterone between Men Receiving Nasal, Intramuscular, and Subcutaneous Pellet Testosterone Therapy: Evaluation of Data from Two Single-Center Randomized Clinical Trials

Autor:	Parris Diaz, Rohit Reddy, Ruben Blachman-Braun, Isaac Zucker, Alexandra Dullea, Daniel C. Gonzalez, Eliyahu Kresch, Ranjith Ramasamy
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	17-alpha-hydroxyprogesterone androgens fertility hypogonadism testosterone Medicine Diseases of the genitourinary system. Urology RC870-923
Zdroj:	The World Journal of Men's Health, Vol 41, Iss 2, Pp 390-395 (2023)
Druh dokumentu:	article
ISSN:	2287-4208 2287-4690
DOI:	10.5534/wjmh.210261
Popis:	Purpose: Testosterone replacement therapy (TRT) can potentially cause decreased spermatogenesis and subsequent infertility. Recent studies have suggested that 17-hydroxyprogesterone (17-OHP) is a reliable surrogate for intratesticular testosterone (ITT) that is essential for spermatogenesis. We evaluated data from two ongoing open-label, randomized, two-arm clinical trials amongst different treatment preparations (Trial I) subcutaneous testosterone pellets (TP) and (Trial II) intranasal testosterone (NT) or intramuscular testosterone cypionate (TC). Materials and Methods: Seventy-five symptomatic hypogonadal men (2 serum testosterone
Databáze:	Directory of Open Access Journals
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