| Autor: |
R. Mahajan, S. Owen, S. Kumar, S. Kazmi, K. Pandey, N. Verma, V. Kumar, A. Harshana, E. Lasry, L. Moretó-Planas, E. Adams, S. Burza |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 130, Iss , Pp S21- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2023.04.051 |
| Popis: |
Intro: People living with HIV (PLHIV) have an increased risk of developing visceral leishmaniasis (VL) and poor outcomes compared to HIV-negative individuals. Here, we aim to establish the prevalence and determinants of asymptomatic Leishmania infection (ALI) and the rate and risk factors for progression of ALI to VL in a cohort of PLHIV in Bihar, India. Methods: We conducted a cross-sectional survey of PLHIV ≥18 years of age with no history or current diagnosis of VL or PKDL at anti-retroviral therapy centres within VL endemic districts of Bihar. ALI was defined as a positive rK39 ELISA, rK39 RDT, and/or qPCR. Additionally, the urinary Leishmania antigen ELISA was evaluated. The ALI and non-ALI cohorts were followed up every three months for 18 months in person and by telephone, respectively. Determinants for ALI were established using logistic regression model. Findings: A total of 1,296 PLHIV enrolled in HIV care, 694 (53.6%) of whom were female and a median age of 39 years (IQR 33–46), were included in the analysis. The baseline prevalence of ALI was 7.4% (n=96). All 96 individuals were positive by rK39 ELISA, while 0.5% (n=6) and 0.4% (n=5) were positive by qPCR and rK39 RDT, respectively. Risk factors for ALI were CD4 counts |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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