Developing a next level integrated genomic surveillance: Advances in the molecular epidemiology of HIV in Germany

Autor: Kirsten Hanke, Vera Rykalina, Uwe Koppe, Barbara Gunsenheimer-Bartmeyer, Dagmar Heuer, Karolin Meixenberger
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Medical Microbiology, Vol 314, Iss , Pp 151606- (2024)
Druh dokumentu: article
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2024.151606
Popis: Advances in the molecular epidemiological studies of the Human Immunodeficiency Virus (HIV) at the Robert Koch Institute (RKI) by laboratory and bioinformatic automation should allow the processing of larger numbers of samples and more comprehensive and faster data analysis in order to provide a higher resolution of the current HIV infection situation in near real-time and a better understanding of the dynamic of the German HIV epidemic. The early detection of the emergence and transmission of new HIV variants is important for the adaption of diagnostics and treatment guidelines. Likewise, the molecular epidemiological detection and characterization of spatially limited HIV outbreaks or rapidly growing sub-epidemics is of great importance in order to interrupt the transmission pathways by regionally adapting prevention strategies. These aims are becoming even more important in the context of the SARS-CoV2 pandemic and the Ukrainian refugee movement, which both have effects on the German HIV epidemic that should be monitored to identify starting points for targeted public health measures in a timely manner. To this end, a next level integrated genomic surveillance of HIV is to be established.
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