| Autor: |
Oliver Nangkuu Deberu, Godfred Acheampong, Bernard Nkrumah, Nana Kwame Ayisi-Boateng, Stephen Opoku Afriyie, Francis Opoku Agyapong, Dorcas Ohui Owusu, Mohamed Mutocheluh, Abass Abdul-Karim, Philip El-Duah, Augustina Angelina Sylverken, Michael Owusu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
COVID, Vol 3, Iss 4, Pp 440-451 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-8112 |
| DOI: |
10.3390/covid3040033 |
| Popis: |
Colonization of SARS-CoV-2 with specific bacteria may either protect or increase the risk of disease severity. This study aimed to identify microbial organisms in the lower respiratory tract and their association with SARS-CoV-2 infection. This was a cross-sectional study conducted between May 2020 and August 2021 at the Tamale Public Health Laboratory in the Northern part of Ghana. RT-PCRs for SARS-CoV-2 and bacteriological cultures were performed on sputum samples collected from suspected COVID-19 patients. Biochemical identification and antimicrobial susceptibility tests were performed on the bacterial isolates. A total of 380 participants were recruited into the study. Most participants were within the 21–30 years age group (29.6%). RT-PCR testing detected SARS-CoV-2 in 118 (31.1%) patients. Headache was found to be associated with SARS-CoV-2 (p = 0.033). Sputum cultures yielded 187 (49.2%) positive bacteria growths. Klebsiella spp. (20.5%), Moraxella catarrhalis (7.9%), and Pseudomonas spp. (6.3%) were the most commonly isolated bacteria. M. catarrhalis, Serratia spp., and Stenotrophomonas maltophilia were significantly associated with SARS-CoV-2 infection. Most of the isolates were resistant to 3rd generation cephalosporins. This study has demonstrated the association between specific bacteria and SARS-CoV-2 infection. Clinicians should investigate possible bacterial co-infections in the management of COVID-19 cases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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