| Autor: |
Jago M. Van Dam, Amy J. Garrett, Luke A. Schneider, Nicolette A. Hodyl, Mitchell R. Goldsworthy, Suzette Coat, Janet A. Rowan, William M. Hague, Julia B. Pitcher |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
EBioMedicine, Vol 31, Iss , Pp 143-149 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3964 |
| DOI: |
10.1016/j.ebiom.2018.04.011 |
| Popis: |
Background: Children exposed to gestational diabetes mellitus (GDM) in utero are at increased risk of neurodevelopmental difficulties, including autism and impaired motor control. However, the underlying neurophysiology is unknown. Methods: Using transcranial magnetic stimulation, we assessed cortical excitability, long-term depression (LTD)-like neuroplasticity in 45 GDM-exposed and 12 control children aged 11–13 years. Data were analysed against salivary cortisol and maternal diabetes severity and treatment (insulin [N = 22] or metformin [N = 23]) during pregnancy. Findings: GDM-exposed children had reduced cortical excitability (p = .003), LTD-like neuroplasticity (p = .005), and salivary cortisol (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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