| Autor: |
Ilona Domracheva, Ruslan Muhamadejev, Marina Petrova, Edvards Liepinsh, Anita Gulbe, Irina Shestakova, Gunars Duburs, Pavel Arsenyan |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Toxicology Reports, Vol 2, Iss C, Pp 377-383 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2214-7500 |
| DOI: |
10.1016/j.toxrep.2015.01.009 |
| Popis: |
Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by 1H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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