Total Panax notoginseng saponin inhibits balloon injury-induced neointimal hyperplasia in rat carotid artery models by suppressing pERK/p38 MAPK pathways
Autor: | Zheng Yang, Hui Zhang, Ming An, Mengni Bian, Miao Song, Xiaohua Guo, Quanli Liu, Min Qiu |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 53, Iss 1 (2019) |
Druh dokumentu: | article |
ISSN: | 1414-431X 1414-431x |
DOI: | 10.1590/1414-431x20199085 |
Popis: | Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawley rats were randomly divided into five groups, sham (control), injury, and low, medium, and high dose TPNS (5, 10, and 20 mg/kg). An in vivo 2F Fogarty balloon-induced carotid artery injury model was established in rats. TPNS significantly and dose-dependently reduced balloon injury-induced neointimal area (NIA) (P |
Databáze: | Directory of Open Access Journals |
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