Total Panax notoginseng saponin inhibits balloon injury-induced neointimal hyperplasia in rat carotid artery models by suppressing pERK/p38 MAPK pathways

Autor:	Zheng Yang, Hui Zhang, Ming An, Mengni Bian, Miao Song, Xiaohua Guo, Quanli Liu, Min Qiu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Total Panax notoginseng saponin Neointimal hyperplasia Vascular injury Phosphorylated extracellular signal-regulated kinase1/2 p38 mitogen-activated protein kinase Medicine (General) R5-920 Biology (General) QH301-705.5
Zdroj:	Brazilian Journal of Medical and Biological Research, Vol 53, Iss 1 (2019)
Druh dokumentu:	article
ISSN:	1414-431X 1414-431x
DOI:	10.1590/1414-431x20199085
Popis:	Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawley rats were randomly divided into five groups, sham (control), injury, and low, medium, and high dose TPNS (5, 10, and 20 mg/kg). An in vivo 2F Fogarty balloon-induced carotid artery injury model was established in rats. TPNS significantly and dose-dependently reduced balloon injury-induced neointimal area (NIA) (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2ef54b61c54f4fc4929fff862cab0819 Zobrazit plný text záznamu View record in DOAJ