miRNA-Based Therapeutics in the Era of Immune-Checkpoint Inhibitors

Autor:	Florian Huemer, Michael Leisch, Roland Geisberger, Nadja Zaborsky, Richard Greil
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	miRNA microRNA immune-checkpoint inhibitor immune-checkpoint blockade predictive ipilimumab Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 14, Iss 2, p 89 (2021)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph14020089
Popis:	MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary target regions on gene transcripts. Thus, miRNAs fine-tune gene expression profiles in a cell-type-specific manner and thereby regulate important cellular functions, such as cell growth, proliferation and cell death. MiRNAs are frequently dysregulated in cancer cells by several mechanisms, which significantly affect the course of the disease. In this review, we summarize the current knowledge on how dysregulated miRNAs contribute to cancer and how miRNAs can be exploited as predictive factors and therapeutic targets, particularly in regard to immune-checkpoint inhibitor therapies.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2ef30622844e46da87665906abebda6e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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