Perbandingan Akurasi Berbagai Formula untuk Mengestimasi Laju Filtrasi Glomerulus pada Penderita Karsinoma Nasofaring Stadium Lanjut Sebelum Mendapat Kemoterapi Cisplatin
| Autor: | Camelia Khairun Nissa, Amaylia Oehadian, Abdul Hadi Martakusumah, Yussy Afriani Dewi |
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| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Majalah Kedokteran Bandung, Vol 47, Iss 1, Pp 42-48 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0126-074X 2338-6223 |
| DOI: | 10.15395/mkb.v47n1.396 |
| Popis: | Cisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus. HARUS 15-30-60 and HADI are new formulas for estimating glomerular filtration rate (GFR) which also calculate tubular function. The aim of this study was to compare the accuracy of Cockroft–Gault (CG), modification of diet in renal disease (MDRD), HARUS 15-30-60 and HADI formula with creatinine clearance in assessing GFR. This was a cross-sectional study with comparative design in patients with advanced NPC before administration of cisplatin in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data were collected from August 2012 to August 2013 and analyzed using ANOVA and concordance correlation coefficient test (CCC). There were 70 patients, consisted of 28 (40%) females and 42 (60%) males with the mean age of 42±12.3 years. LFG estimations based on MDRD, CG, and HADI were different from the creatinine clearance (p0.05). HARUS 15-30-60 with creatinine clearance had CCC 0.401 was greater than CG (CCC=0.387), HADI (CCC=0.258), and MDRD (CCC=0.136). In conclusion, HARUS 15-30-60 formula is more accurate than CG, HADI, and MDRD formula in assessing renal function (GFR) in patients with advanced NPC. |
| Databáze: | Directory of Open Access Journals |
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