| Autor: |
DIAO Hua-qiong, LI Xiao-li, LIN Liang-yin, LIU Hai-peng, CHEN Hong-jing, DING Hai-yue, WEI Dan |
| Jazyk: |
čínština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Jichu yixue yu linchuang, Vol 40, Iss 11, Pp 1542-1545 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1001-6325 |
| Popis: |
Alzheimer's disease is the most common dementia in the aged population and is characterizd by hidden attack and progressive development. Some studies showed that exosomal microRNAs(miRNAs) regulates the shearing of amyloid precusor protein,deposition of beta-amyloid peptides(Aβ) and phosphorylation of Tau protein, influencing the generation of neuritic plaques and neurofibrillary tangles. In addition, special miRNAs can be transpor-ted by exsome across blood-brain-barrier and inhibit Tau phosphorylation. Measuring the expression profile of exosomal miRNAs in the peripheral blood may be a non-invasive diagnosis and treatment method of AD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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