A novel route to 3-hydroxy-16,17-seco-estrone derivatives
| Autor: | Jovanović-Šanta Suzana S., Pejanović Vjera M., Petrović Julijana A. |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 64, Iss 5-6, Pp 391-394 (1999) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC9906391J |
| Popis: | Starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (1b), 17-tosylate 2b and also 17-chloro-, 17-bromo- and 17-iodo-derivatives 4b, 5b, and 6b, were obtained. The fluoro-derivative 3b was obtained from2b in the reaction with tetrabutyl ammonium fluoride. The deprotection of the 3-hydroxyl group was achieved by action of hydrogen in presence of Pd/C as a catalyst, yielding six new 3-hydroxy-16,17-seco-estrone derivatives. |
| Databáze: | Directory of Open Access Journals |
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