Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo
| Autor: | Hea Jung Yang, Jong-Ho Kim, Jung Hee Shim, Chan Yeong Heo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Adipocyte, Vol 11, Iss 1, Pp 643-652 (2022) |
| Druh dokumentu: | article |
| ISSN: | 21623945 2162-397X 2162-3945 |
| DOI: | 10.1080/21623945.2022.2149121 |
| Popis: | ABSTRACTSoft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to ageing, and mastectomy in breast cancer; fat grafting is commonly performed to restore these defects. Although various enrichment strategies have been studied, novel therapeutics that are cost-effective, safe, technologically easy to manufacture, and minimally invasive are required. In this study, we identified a novel peptide derived from plasminogen, named plasminogen-derived peptide-1 (PLP-1), which showed adipogenic differentiation potential and led to an increase in the expression levels of adiponectin, C1Q and collagen domain containing protein, fatty acid-binding protein 4, and CCAAT/enhancer-binding protein-alpha. In vivo experiments confirmed an increase in the rate of adipocyte differentiation and the expression levels of CD31 in the PLP-1-treated mice groups. These results suggested that PLP-1 plays an important role in promoting the differentiation of preadipocytes and may be useful for developing therapeutic approaches to treat adipose tissue defects. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|