Synthesis of novel N-substituted benzyl N-(1,3-benzothiazol-2-yl) acetamides and their in vitro antibacterial activities
| Autor: | Can Sakarya Handan, Görgün Kamuran, Filik Işcen Cansu |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 89, Iss 9, Pp 1133-1145 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC231020059C |
| Popis: | The novel Schiff bases 3a–d were synthesized by reacting 6-methyl-2-aminobenzothiazole and different substituted benzaldehydes. Afterwards, the obtained Schiff bases were reduced with NaBH4 to form amine compounds 4a–d. In the final step, reaction of the amine with chloroacetyl chloride gave the novel amide derivatives 5a–d. The structures of the all novel synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, ESI MS, HETCOR, 2D (1H–1H) COSY spectra and elemental analyses. The antimicrobial activities of the novel synthesized compounds, were tested against some Gram-positive and Gram-negative bacterial as well as fungal species and the results were discussed. |
| Databáze: | Directory of Open Access Journals |
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