Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing
| Autor: | Yani Feng, Lina Ma, Xi Chen, Yitong Zhang, Zine Cao, Yuqi Yuan, Yushan Xie, Haiqin Liu, Yewen Shi, Xiaoyong Ren |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Frontiers in Pediatrics, Vol 10 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2296-2360 32798504 |
| DOI: | 10.3389/fped.2022.1027894 |
| Popis: | BackgroundAs an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment in children with sleep-disordered breathing (SDB). The main aim of this study was to compare the levels of BDNF and tyrosine kinase receptor B (TrkB) in normal children and those with obstructive sleep apnea (OSA) and primary snoring (PS) and to explore a possible link between BDNF/TrkB, inflammation, and SDB with cognitive impairment in children.MethodsA total of 44 OSA children and 35 PS children who completed polysomnography between October 2017 and October 2019 were enrolled. At the same time, 40 healthy children during the same period were included as a control. Enzyme-linked immunosorbent assay was used to measure serum indices of BDNF, TrkB, interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α). Correlation and pooled analyses were performed between the cognitive scores and four serological indicators. Logistic regression was used to analyze the risk factors for cognitive impairment.ResultsSignificant differences were found in serum BDNF, TrkB, IL-1β, and TNF-α between the three groups (all P |
| Databáze: | Directory of Open Access Journals |
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