Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Autor: Hussein F.. Zohdi, Ayman M. Saleh, Ibrahim M. Abdou
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Molecules, Vol 9, Iss 3, Pp 109-116 (2004)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/90300109
Popis: 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
Databáze: Directory of Open Access Journals