| Autor: |
Xianchun Gao, Gang Li, Jingyu Deng, Lulu Zhao, Weili Han, Nannan Zhang, Yunhe Gao, Linbin Lu, Shibo Wang, Jun Yu, Junya Yan, Gan Zhang, Rui Peng, Rupeng Zhang, Yu Fu, Fang He, Junguo Hu, Wanqing Wang, Ping Fan, Cen Si, Peng Gao, Han Liang, Huanqiu Chen, Gang Ji, Lei Shang, Qingchuan Zhao, Zhiyi Zhang, Shaoqi Yang, Zhenning Wang, Hongqing Xi, Yingtai Chen, Kaichun Wu, Yongzhan Nie |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
The Lancet Regional Health. Western Pacific, Vol 45, Iss , Pp 101031- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6065 |
| DOI: |
10.1016/j.lanwpc.2024.101031 |
| Popis: |
Summary: Background: Recurrence following radical resection in patients with stage IB gastric cancer (GC) is not uncommon. However, whether postoperative adjuvant chemotherapy could reduce the risk of recurrence in stage IB GC remains contentious. Methods: We collected data on 2110 consecutive patients with pathologic stage IB (T1N1M0 or T2N0M0) GC who were admitted to 8 hospitals in China from 2009 to 2018. The survival of patients who received adjuvant chemotherapy was compared with that of postoperative observation patients using propensity score matching (PSM). Two survival prediction models were constructed to estimate the predicted net survival gain attributable to adjuvant chemotherapy. Findings: Of the 2110 patients, 1344 received adjuvant chemotherapy and 766 received postoperative observation. Following the 1-to-1 matching, PSM yielded 637 matched pairs. Among matched pairs, adjuvant chemotherapy was not associated with improved survival compared with postoperative observation (OS: hazard ratio [HR], 0.72; 95% CI, 0.52–1.00; DFS: HR, 0.91; 95% CI, 0.64–1.29). Interestingly, in the subgroup analysis, reduced mortality after adjuvant chemotherapy was observed in the subgroups with elevated serum CA19-9 (HR, 0.22; 95% CI, 0.08–0.57; P = 0.001 for multiplicative interaction), positive lymphovascular invasion (HR, 0.32; 95% CI, 0.17–0.62; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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