| Autor: |
Sumanta Chatterjee, Vasudeva Bhat, Alexei Berdnikov, Jiahui Liu, Guihua Zhang, Edward Buchel, Janice Safneck, Aaron J. Marshall, Leigh C. Murphy, Lynne-Marie Postovit, Afshin Raouf |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
iScience, Vol 19, Iss , Pp 388-401 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2019.07.034 |
| Popis: |
Summary: Breast cancer-induced activated fibroblasts support tumor progression. However, the role of normal fibroblasts in tumor progression remains controversial. In this study, we used modified patient-derived organoid cultures and demonstrate that constitutively secreted cytokines from normal breast fibroblasts initiate a paracrine signaling mechanism with estrogen receptor-positive (ER+) breast cancer cells, which results in the creation of an interleukin (IL)-1β-enriched microenvironment. We found that this paracrine signaling mechanism is shared between normal and activated fibroblasts. Interestingly, we observed that in reconstructed tumor microenvironment containing autologous ER+ breast cancer cells, activated fibroblasts, and immune cells, tamoxifen is more effective in reducing tumor cell proliferation when this paracrine signaling is blocked. Our findings then suggest that ER+ tumor cells could create a growth-promoting environment without activating stromal fibroblasts and that in breast-conserving surgeries, normal fibroblasts could be a significant modulator of tumor recurrence by enhancing the proliferation of residual breast cancer cells in the tumor-adjacent breast tissue. : Molecular Mechanism of Behavior; Functional Aspects of Cell Biology; Cancer Subject Areas: Molecular Mechanism of Behavior, Functional Aspects of Cell Biology, Cancer |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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