| Autor: |
Elham Ghorbani Jazar, Seyedeh Parisa Chavoshi Tarzjani, Zahra Sadeghi, Shekoofe Alaie, Seyed Abolhassan Shahzadeh Fazeli |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Shahrekord University of Medical Sciences, Vol 22, Iss 4, Pp 155-158 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2717-0071 |
| DOI: |
10.34172/jsums.2020.25 |
| Popis: |
Multiple sclerosis (MS) is a chronic disease characterized by degeneration of the central nervous system (CNS). High levels of Neurofilament heavy chain (NEFH) in cerebrospinal fluid (CSF) is associated with MS. 40 MS patients and 40 controls genotyped by polymerase chain reaction (PCR) and Sanger sequencing. Genotypic and allelic distributions were compared between cases and controls. Fisher test was used to estimate the risk of MS associated with genotypes. We showed that NEFH, 1084-244G>A gene polymorphism, has no significant association with the susceptibility or severity of MS in Iranian patients (P = 0.737). Further prospective studies are required for confirmation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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