| Autor: |
James Eills, Marc Azagra, David Gómez-Cabeza, Michael C.D. Tayler, Irene Marco-Rius |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Magnetic Resonance Open, Vol 18, Iss , Pp 100144- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-4410 |
| DOI: |
10.1016/j.jmro.2023.100144 |
| Popis: |
From complex-mixture analysis to in vivo molecular imaging, applications of liquid-state nuclear spin hyperpolarization have expanded widely over recent years. In most cases, hyperpolarized solutions are generated ex situ and transported from the polarization instrument to the measurement device. The sample hyperpolarization usually survives this transport, since the changes in magnetic fields that are external to the sample are typically adiabatic (slow) with respect to the internal nuclear spin dynamics. The passage of polarized samples through weakly magnetic components such as stainless steel syringe needles and ferrules is not always adiabatic, which can lead to near-complete destruction of the magnetization. To avoid this effect becoming “folklore” in the field of hyperpolarized NMR, we present a systematic investigation to highlight the problem and investigate possible solutions. Experiments were carried out on: (i) dissolution-DNP-polarized [1-13C]pyruvate with NMR detection at 1.4T, and (ii) 1.5-T-polarized H2O with NMR detection at 2.5μT. We show that the degree of adiabaticity of solutions passing through metal parts is intrinsically unpredictable, likely depending on many factors such as solution flow rate, degree of remanent ferromagnetism in the metal, and nuclear spin species. However, the magnetization destruction effects can be suppressed by application of an external field on the order of 0.1–10mT. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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