The Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer

Autor: Yongkun Fang, Cheng Yan, Qi Zhao, Bin Zhao, Yiqun Liao, Yuji Chen, Daorong Wang, Dong Tang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 16 (2022)
Druh dokumentu: article
ISSN: 1179-5549
11795549
DOI: 10.1177/11795549221130549
Popis: The large number of microbes found in the gut are involved in various critical biological processes in the human body and have dynamic and complex interactions with the immune system. Disruptions in the host’s gut microbiota and the metabolites produced during fermentation promote the development of intestinal inflammation and colorectal cancer (CRC). Toll-like receptors (TLRs) recognize specific microbial-associated molecular patterns specific to microorganisms whose signaling is involved in maintaining intestinal homeostasis or, under certain conditions, mediating dysbiosis-associated intestinal inflammation. The signaling pathways of TLRs are described first, followed by a discussion of the interrelationship between gut microbes and TLRs, including the activation of TLRs by gut microbes and the effect of TLRs on the distribution of gut microbiota, particularly the role of microbes in colorectal carcinogenesis via TLRs. Finally, we discuss the potential roles of various TLRs in colorectal cancer.
Databáze: Directory of Open Access Journals
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