Retroperitoneal Castleman's tumor and paraneoplastic pemphigus: report of a case and review of the literature

Autor: Jacobi Christoph A, Hartmann Jens, Braumann Chris, Menenakos Charalambos
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 5, Iss 1, p 45 (2007)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/1477-7819-5-45
Popis: Abstract Background Castleman's disease is a rare lymphoproliferative syndrome. Its etiology and pathogenesis are unclear. The disease can be occasionally associated with a paraneoplastic pemphigus (PNP), an autoimmune mucocutaneous disorder commonly seen in neoplasms of lymphocytic origin. Case presentation We present a case of a 63-year old male patient who was referred for surgical treatment of a lately diagnosed retroperitoneal pelvic mass. The patient had been already treated for two years due to progressive diffuse cutaneous lesions histologically consistent with lichen ruber verucosus and pemphigus vulgaris. Intraoperatively a highly vascularized solid mass occupying the small pelvis was resected after meticulous vascular ligation and hemostasis. After surgery and following immunosuppressive treatment a clear remission of the skin lesions was observed. Conclusion Castleman's tumor should be always suspected when a retroperitoneal mass is combined with PNP. In a review of the literature we found 37 additional cases. Complete surgical resection of the tumor can be curative in most of the cases.
Databáze: Directory of Open Access Journals
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