In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Autor: Vivian Leliebre-Lara, Lianet Monzote Fidalgo, Eva-Maria Pferschy-Wenzig, Olaf Kunert, Clara Nogueiras Lima, Rudolf Bauer
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Molecules, Vol 21, Iss 8, p 1045 (2016)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules21081045
Popis: Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.
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