A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis

Autor: Yutaka Takahara, Kouichi Yamamura, Saki Matsuura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Rieko Oikawa, Yuki Fujimoto, Taku Oikawa, Kazuhiro Osanai, Yoshimichi Ueda, Shiro Mizuno
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Respiratory Medicine Case Reports, Vol 30, Iss , Pp 101124- (2020)
Druh dokumentu: article
ISSN: 2213-0071
DOI: 10.1016/j.rmcr.2020.101124
Popis: A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.
Databáze: Directory of Open Access Journals