Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats

Autor:	Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Mehmet Akif Ovali, Orkut Güçlü, Ufuk Demir, Ayten Doğan, Metehan Uzun
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	preeclampsia heart fetus apoptosis oxidative stress melatonin Gynecology and obstetrics RG1-991
Zdroj:	Hypertension in Pregnancy, Vol 39, Iss 4, Pp 429-443 (2020)
Druh dokumentu:	article
ISSN:	1064-1955 1525-6065 10641955
DOI:	10.1080/10641955.2020.1802595
Popis:	Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion: Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.
Databáze:	Directory of Open Access Journals
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