Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
Autor: | Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Mehmet Akif Ovali, Orkut Güçlü, Ufuk Demir, Ayten Doğan, Metehan Uzun |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Hypertension in Pregnancy, Vol 39, Iss 4, Pp 429-443 (2020) |
Druh dokumentu: | article |
ISSN: | 1064-1955 1525-6065 10641955 |
DOI: | 10.1080/10641955.2020.1802595 |
Popis: | Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion: Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring. |
Databáze: | Directory of Open Access Journals |
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