| Autor: |
Jassem Nizar Awish, Alhammid Shaimaa Nazar Abd |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Acta Marisiensis - Seria Medica, Vol 70, Iss 2, Pp 42-49 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2668-7763 |
| DOI: |
10.2478/amma-2024-0011 |
| Popis: |
Background and objective: Self-nanomicellizing solid dispersion SNMSD is a new formulation that combines solid dispersion and nanomicelle strategies; the strategy involves utilizing a suitable carrier that self-assembles into nanomicelles when interacting with gastrointestinal fluids. Canagliflozin, a sodium-glucose cotransporter-2 inhibitor for treating type 2 diabetes, has been linked to poor absorption due to its insolubility in aqueous media. The study aimed to create self-nanomicellizing solid dispersion systems for canagliflozin to overcome its pharmaceutical limitations and improve oral bioavailability. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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