| Autor: |
Henry W. Chase, Simona Graur, Amelia Versace, Tsafrir Greenberg, Lisa Bonar, Robert Hudak, Gregory J. Quirk, Ben D. Greenberg, Steven A. Rasmussen, Suzanne N. Haber, Mary L. Phillips |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 28, Iss , Pp 102404- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2020.102404 |
| Popis: |
Obsessive-Compulsive Disorder (OCD) is characterized by repetitive avoidance behavior which is distressing and associated with marked impairment of everyday life. Recently, paradigms have been designed to explore the hypothesis that avoidance behavior in OCD is consistent with a formal conception of habit. Such studies have involved a devaluation paradigm, in which the value of a previously rewarded cue is altered so that avoidance is no longer necessary. We employed a rule-based avoidance task which included a devaluation, examining behavioral performance on the task and their neural correlates using functional MRI in groups of participants with OCD (n = 44) and healthy control participants (n = 46). Neuroimaging data were analyzed using a general linear model (GLM), modelling valued, devalued and control cues, as well as feedback events. First, while no overall effect of OCD was seen on devaluation performance, patients with longer illness duration showed poorer devaluation performance (χ2 = 13.84, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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