Antiviral Resistance of Splenocytes in Aged Mice
| Autor: | Ewa Zaczyńska, Jolanta Artym, Maja Kocięba, Timo Burster, Marian Kruzel, Maria Paprocka, Michał Zimecki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Polish Journal of Microbiology, Vol 66, Iss 1 (2017) |
| Druh dokumentu: | article |
| ISSN: | 17331331 1733-1331 2544-4646 |
| DOI: | 10.5604/17331331.1235002 |
| Popis: | We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|