Acute respiratory distress syndrome due to monkeypox virus

Autor: Tona Tchoubou, Rima El-Hosni, Marion Dollat, Pierre Jaquet, Celine Tournus, Yacine Tandjaoui-Lambiotte, Daniel Da Silva
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: European Journal of Case Reports in Internal Medicine (2023)
Druh dokumentu: article
ISSN: 2284-2594
DOI: 10.12890/2023_004126
Popis: We report the first case of monkeypox virus (MPXV) associated acute respiratory distress syndrome (ARDS). A 34-year-old French woman with no medical history was admitted to the intensive care unit (ICU) for fever, altered mental status, hypotension and hypoxaemia. She presented with a diffuse skin rash with vesiculopustular lesions involving the four limbs and perineal ulcers with a skin swab positive for MPXV. On day 2, the patient presented moderate ARDS requiring invasive mechanical ventilation. She also had pleural empyema due to Streptococcus pyogenes. MPXV PCR was positive in the bronchoalveolar lavage, the pleural effusion and the blood. The patient was treated with tecovirimat. Despite the treatment, she had persistent viraemia for at least ten days. The patient condition rapidly improved; she was weaned from mechanical ventilation on day 18 despite the persistence of radiological lung opacities. She fully recovered and was discharged home on day 38 after admission.
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