Heritable influence of DBH on adrenergic and renal function: twin and disease studies.
| Autor: | Dalal N Pasha, Jason T Davis, Fangwen Rao, Yuqing Chen, Gen Wen, Maple M Fung, Manjula Mahata, Kuixing Zhang, Danuta Trzebinska, Maja Mustapic, C Makena Hightower, Michael S Lipkowitz, Ming Ji, Michael G Ziegler, Caroline M Nievergelt, Daniel T O'Connor |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 8, Iss 12, p e82956 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 70415811 |
| DOI: | 10.1371/journal.pone.0082956 |
| Popis: | Elevated sympathetic activity is associated with kidney dysfunction. Here we used twin pairs to probe heritability of GFR and its genetic covariance with other traits.We evaluated renal and adrenergic phenotypes in twins. GFR was estimated by CKD-EPI algorithm. Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis probed reproducibility of DBH genetic effects. Effect of DBH genetic variation on renal disease was tested in the NIDDK-AASK cohort.Norepinephrine secretion rose across eGFR tertiles while eGFR fell (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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