Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.
| Autor: | Ajeet Pratap Singh, Rudra Nayan Das, Gururaj Rao, Aman Aggarwal, Soeren Diegelmann, Jan Felix Evers, Hrishikesh Karandikar, Matthias Landgraf, Veronica Rodrigues, K Vijayraghavan |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | PLoS Genetics, Vol 9, Iss 4, p e1003452 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1553-7390 1553-7404 |
| DOI: | 10.1371/journal.pgen.1003452 |
| Popis: | Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts. |
| Databáze: | Directory of Open Access Journals |
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