Bisphosphonate-induced atypical femoral shaft fracture: A case report

Autor: Ameer Mustafa Farrukh, Ligia Carolina Flores Reyes, Gabriela Sayonara Lopez Capa, Tania Beatriz Marin Padilla, Vyshnavidevi Sunkara, Sandhya Dhakal
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Radiology Case Reports, Vol 18, Iss 11, Pp 4048-4051 (2023)
Druh dokumentu: article
ISSN: 1930-0433
DOI: 10.1016/j.radcr.2023.08.040
Popis: Osteoporosis is an important cause of fractures in postmenopausal women. Bisphosphonates are the first line of treatment for osteoporosis. However, long-term use of these medications has been related to atypical femoral fractures (AFF). We present a case of a 71-year-old postmenopausal woman, with a history of osteoporosis being treated with bisphosphonates for 6 years. The patient developed pain in her left hip and thigh over a period of 3-4 months. Radiographic studies showed an AFF and she was managed conservatively. Stopping bisphosphonate therapy should be an initial step in managing or limiting the progression of AFF. A drug holiday should be considered in patients who have been treated for more than 3-5 years to prevent AFFs. The risk of developing AFFs should never be ignored in this subset of patients.
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