Aflibercept Treatment Results and Association with Baseline Characteristics in Cases of Newly Diagnosed Neovascular Age-Related Macular Degeneration
| Autor: | Pelin Kıyat, Jale Menteş, Serhad Nalçacı, Filiz Afrashi, Mine Barış |
|---|---|
| Jazyk: | English<br />Turkish |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Türk Oftalmoloji Dergisi, Vol 51, Iss 3, Pp 161-168 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1300-0659 2147-2661 |
| DOI: | 10.4274/tjo.galenos.2020.52460 |
| Popis: | Objectives:To evaluate functional and anatomical responses to intravitreal aflibercept (IVA) treatment in newly diagnosed and untreated neovascular age-related macular degeneration (nvAMD) cases and to investigate the effect of baseline lesion characteristics on anatomical responses.Materials and Methods:This prospective, cross-sectional study included a series of 139 eyes of 133 patients that were diagnosed with active nvAMD and had not been treated. All eyes were subjected to complete ophthalmological examination, spectral-domain optical coherence tomography and fluorescein angiography, and 42 eyes also underwent indocyanine green angiography. IVA treatment was performed using a “treat and extend” regimen after 3 injections at 4-6 weeks intervals. Anatomical and functional responses at 4 weeks after the last injection were evaluated in eyes that completed 3 injections and the subgroup of eyes that completed 6 IVA injections. The effect of baseline lesion characteristics on IVA treatment results was also investigated.Results:All 139 eyes included in the study received 3 IVA injections (group 1) and 62 received 6 IVA injections. Both groups showed statistically significant improvement in best-corrected visual acuity (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|