| Autor: |
R. De Caro, A. Parenti, I. Castagliuolo, A. Amagliani, V. Macchi, A. Porzionato |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
European Journal of Histochemistry, Vol 53, Iss 3, Pp 135-142 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1121-760X |
| DOI: |
10.4081/ejh.2009.135 |
| Popis: |
In the present study we investigated, through immunohistochemistry, the presence and location of neurotensin receptor 1 (NTR1) in the peripheral ganglia and carotid body of 16 humans and 5 rats. In both humans and rats, NTR1 immunostained ganglion cells were found in superior cervical ganglia (57.4±11.6% and 72.4±11.4%, respectively, p0.05) and parasympathetic ganglia (52.1±14.1% and 59.4±14.0%, p>0.05), supporting a modulatory role for NT in these ganglia. Positivity was also detected in 45.6±9.2% and 50.8±6.8% of human and rat type I glomic cells, respectively, whereas type II cells were negative. Our findings suggest that NT produced by type I cells acts in an autocrine or paracrine way on the same cell type, playing a modulatory role on chemoception. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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