A case of Clival Tuberculosis and associated meningitis

Autor: William Peter Flynn, Yevedzo Ntuli, Henry Zhang, Simon Tiberi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 25, Iss , Pp 100273- (2021)
Druh dokumentu: article
ISSN: 2405-5794
DOI: 10.1016/j.jctube.2021.100273
Popis: Herein we report a 30-year-old man presenting with fevers, headaches and weight loss. On admission he was disorientated and demonstrated no focal signs of neurological deficit. Magnetic resonance imaging revealed a large area of abnormal bone marrow signal centred within the clivus with extension into the sphenoid sinus and signs of associated basal meningitis. A sphenoid sinus biopsy was performed and proved non diagnostic. The patient was treated empirically with antitubercular therapy (ATT). Lumbar puncture provided cerebrospinal fluid from which Mycobacterium tuberculosis (MTB) was isolated 35 days later. His clinical course was complicated by development of communicating hydrocephalus requiring placement of a ventriculoperitoneal shunt and addition of thalidomide. The patient was discharged following a ten-week admission with complete resolution of symptoms and remains well two years later.
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