Post-translational control of RIPK3 and MLKL mediated necroptotic cell death [version 1; referees: 4 approved]
| Autor: | James M. Murphy, James E. Vince |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Biocatalysis
Cancer Therapeutics Cell Growth & Division Cell Signaling Cell Signaling & Trafficking Structures Cellular Death & Stress Responses Cellular Microbiology & Pathogenesis Control of Gene Expression Gastrointestinal Physiology Immunity to Infections Innate Immunity Leukocyte Signaling & Gene Expression Membranes & Sorting Protein Chemistry & Proteomics Medicine Science |
| Zdroj: | F1000Research, Vol 4 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.7046.1 |
| Popis: | Several programmed lytic and necrotic-like cell death mechanisms have now been uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3)-mixed lineage kinase domain-like (MLKL)-dependent necroptosis pathway. Genetic experiments have shown that programmed necrosis, including necroptosis, can play a pivotal role in regulating host-resistance against microbial infections. Alternatively, excess or unwarranted necroptosis may be pathological in autoimmune and autoinflammatory diseases. This review highlights the recent advances in our understanding of the post-translational control of RIPK3-MLKL necroptotic signaling. We discuss the critical function of phosphorylation in the execution of necroptosis, and highlight the emerging regulatory roles for several ubiquitin ligases and deubiquitinating enzymes. Finally, based on current evidence, we discuss the potential mechanisms by which the essential, and possibly terminal, necroptotic effector, MLKL, triggers the disruption of cellular membranes to cause cell lysis. |
| Databáze: | Directory of Open Access Journals |
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