Copper-catalyzed N-arylation of amines with aryliodonium ylides in water

Autor: Kasturi U. Nabar, Bhalchandra M. Bhanage, Sudam G. Dawande
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1008-1014 (2023)
Druh dokumentu: article
ISSN: 1860-5397
DOI: 10.3762/bjoc.19.76
Popis: Copper sulfate catalyzed an efficient, inexpensive, and environment-friendly protocol that has been developed for N-arylation of amines with 1,3-cyclohexadione-derived aryliodonium ylides in water as a green solvent. Aromatic primary amines substituted with electron-donating as well as electron-withdrawing groups on the aryl ring reacted smoothly with iodonium ylides to give the corresponding diarylamines with good to excellent yields. Also, secondary amines underwent N-arylation to deliver tertiary amines with moderate yields.
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