Investigation of grape sap on wingless/integrated and β-catenin genes expression with histological factors on the hair follicle in rat

Autor: Mohammad Kazemi, Mohammad-Mohsen Taghavi, Ahmad Shabanizadeh, Zahra Taghipour, Ayat Kaeidi, Mahdi Shariati-Kohbanani
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Research in Pharmaceutical Sciences, Vol 15, Iss 4, Pp 350-357 (2020)
Druh dokumentu: article
ISSN: 1735-5362
1735-9414
86112139
DOI: 10.4103/1735-5362.293513
Popis: Background and purpose: Natural products are used to improve the damage caused by harmful reagents in various pathological situations. This study investigated the effect of grape sap as a natural product with antioxidant properties on follicle cell proliferation in bleomycin (as a chemotherapy agent with toxic effects on hair growth) treated rats skin. Experimental approach: The bleomycin treated rats were administrated grape sap. Wingless/integrated (wnt) and β-catenin gene expression as follicle proliferative markers were evaluated using real-time polymerase chain reaction. Furthermore, histological factors and total antioxidant capacity were evaluated. Findings / Results: The data showed that, grape sap increased the number of anagenic hair follicle in grape sap (100 mg/kg) group (P < 0.001), sebaceous glands (P < 0.001), blood vessel density (P < 0.001), and hair growth length (P < 0.001). Also, wnt and β-catenin gene expression was elevated. The data showed that wnt and β-catenin gene expression were elevated in grape sap treated animals versus bleomycin group (P < 0.01 and 0.001, respectively). Conclusion and implications: Our finding showed that grape sap can be effective in increasing hair growth a gains bleomycin toxic effects on skin hair growth.
Databáze: Directory of Open Access Journals
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