Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation

Autor:	Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Danilovskyi Serhij V., Rudnytska Olha V., Halkin Oleh V., Kryvdiuk Iryna V., Smeshkova Maria V., Yakymchuk Mykhailo M., Bezrodnyi Borys H., Minchenko Oleksandr H.
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	ern1 knockdown ide pitrm1 mrna expression microrna hypoxia glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Endocrine Regulations, Vol 54, Iss 3, Pp 183-195 (2020)
Druh dokumentu:	article
ISSN:	1336-0329 2020-0021
DOI:	10.2478/enr-2020-0021
Popis:	Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of metabolism through ERN1 signaling as well as hypoxia, glucose and glutamine deprivations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2e32ed13155943aabe06d3720f9c0857 Zobrazit plný text záznamu View record in DOAJ