Distribution of genetically characterized yeasts and its antifungals susceptibility in the hospital environment
| Autor: | CAROLINA L. GONÇALVES, PEDRO R. DOS SANTOS, EVANDRO C. PEREIRA, CRISTINA H. DE FREITAS, MARCOS R.A. FERREIRA, FABRÍCIO R. CONCEIÇÃO, PATRÍCIA S. NASCENTE |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 93, Iss suppl 3 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765202120201070 |
| Popis: | Abstract Candida spp. is one of the main pathogens associated with nosocomial infection in Brazil and worldwide. The aim of this study was to evaluate the distribution of Candida yeasts in the ICU and their susceptibility to the antifungal agents terbinafine and fluconazole. The samples were collected by swabbing nine surfaces in the ICU of a hospital located in Pelotas, RS. These isolates were genetically characterized by sequencing the internal transcript spacer (ITS) using the primers ITS1 and ITS4. The test against antifungals was performed by Microdilution in Broth (CLSI-M27-A4). 64 yeasts identified as Candida parapsilosis (45.31%; n = 29), Meyerozyma (Pichia) guilliermondii (28.12%; n = 18), Claviceps lusitaneae (25%; n = 16) and Candida tropicalis (1, 56%; n = 1) mostly at the counter used for handling medicines and food distribution (68.75%; n = 44). Susceptibility to antifungals varied between species. These results describe potentially pathogenic Candida species as contaminants in the ICU environment. The study environment is a potential source of exogenous infection for hospitalized patients. |
| Databáze: | Directory of Open Access Journals |
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