Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir
| Autor: | Daisy Maria Machado, Aída de Fátima Barbosa Gouvêa, Maria Regina Cardoso, Suênia Vasconcelos Beltrão, Kelly Simone Cunegundes, Fabiana Bononi, Fernanda Almeida, Kaline Cavalheiro, Daniela Souza Araújo de Angelis, Regina Célia de Menezes Succi |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 11, Iss 1, Pp 16-19 |
| Druh dokumentu: | article |
| ISSN: | 1678-4391 1413-8670 |
| DOI: | 10.1590/S1413-86702007000100006 |
| Popis: | This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to > 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was assessed. Sixteen (55.2%) and 19 (65.5%) of 29 patients exhibited good virological and immunological responses, respectively. Baseline CD4+ values (>500) predicted both virological and immunological responses (p |
| Databáze: | Directory of Open Access Journals |
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