Glycosylated-Chitosan Derivatives: A Systematic Review

Autor: Pasquale Sacco, Michela Cok, Francesca Scognamiglio, Chiara Pizzolitto, Federica Vecchies, Andrea Marfoglia, Eleonora Marsich, Ivan Donati
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecules, Vol 25, Iss 7, p 1534 (2020)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules25071534
Popis: Chitosan derivatives, and more specifically, glycosylated derivatives, are nowadays attracting much attention within the scientific community due to the fact that this set of engineered polysaccharides finds application in different sectors, spanning from food to the biomedical field. Overcoming chitosan (physical) limitations or grafting biological relevant molecules, to mention a few, represent two cardinal strategies to modify parent biopolymer; thereby, synthetizing high added value polysaccharides. The present review is focused on the introduction of oligosaccharide side chains on the backbone of chitosan. The synthetic aspects and the effect on physical-chemical properties of such modifications are discussed. Finally, examples of potential applications in biomaterials design and drug delivery of these novel modified chitosans are disclosed.
Databáze: Directory of Open Access Journals