Sickle cells are not necessarily protective against falciparum- A case report

Autor: Jess Elizabeth Rasalam, Snehil Kumar, K Sujith, N A Fouzia, Arpana Palle, Dolly Daniel, Sukesh Chandran Nair
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Asian Journal of Transfusion Science, Vol 16, Iss 2, Pp 266-268 (2022)
Druh dokumentu: article
ISSN: 0973-6247
1998-3565
DOI: 10.4103/ajts.ajts_122_21
Popis: The relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis and parasite death. Although patients with sickle cell trait are relatively protected, malaria can often lead to marked anemia in them due to hemolysis. We report an unusual case of a child with homozygous SCD presenting with falciparum malaria and had hyper parasitemia and severe anemia which completely resolved following treatment. Clinical suspicion in our case arose considering the endemic nature of malaria in our country. The two overlapping injuries to spleen reduced the clearance of parasites by the spleen as evidenced by high parasite load. Our case report reinforces malaria as a cause of clinical worsening of SCD and highlights the importance of a multifactorial approach in the management of worsening anemia in SCD.
Databáze: Directory of Open Access Journals
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