Impact of uncertainties in exposure assessment on estimates of thyroid cancer risk among Ukrainian children and adolescents exposed from the Chernobyl accident.

Autor: Mark P Little, Alexander G Kukush, Sergii V Masiuk, Sergiy Shklyar, Raymond J Carroll, Jay H Lubin, Deukwoo Kwon, Alina V Brenner, Mykola D Tronko, Kiyohiko Mabuchi, Tetiana I Bogdanova, Maureen Hatch, Lydia B Zablotska, Valeriy P Tereshchenko, Evgenia Ostroumova, André C Bouville, Vladimir Drozdovitch, Mykola I Chepurny, Lina N Kovgan, Steven L Simon, Victor M Shpak, Ilya A Likhtarev
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: PLoS ONE, Vol 9, Iss 1, p e85723 (2014)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0085723
Popis: The 1986 accident at the Chernobyl nuclear power plant remains the most serious nuclear accident in history, and excess thyroid cancers, particularly among those exposed to releases of iodine-131 remain the best-documented sequelae. Failure to take dose-measurement error into account can lead to bias in assessments of dose-response slope. Although risks in the Ukrainian-US thyroid screening study have been previously evaluated, errors in dose assessments have not been addressed hitherto. Dose-response patterns were examined in a thyroid screening prevalence cohort of 13,127 persons aged
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