| Autor: |
Zheng Zhuang, Xueqing Zhong, Qinghua Li, Tian Liu, Qing Yang, Guo-Qiang Lin, Qing-Li He, Qunfei Zhao, Wen Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Bioresources and Bioprocessing, Vol 10, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2197-4365 |
| DOI: |
10.1186/s40643-023-00625-8 |
| Popis: |
Abstract Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain. Graphical Abstract |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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