(3,5-Di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone

Autor:	Katrina E. Doherty, Geoffrey P. Wadey, Arturo León Sandoval, Nicholas E. Leadbeater
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	oxoammonium salt oxidative functionalization aldehyde pyrazole acyl pyrazole green chemistry Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2022, Iss 4, p M1468 (2022)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1468
Popis:	The acyl pyrazole derivative (3,5-di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone was prepared simply and rapidly in 86% isolated yield by means of an oxidative functionalization reaction of an aldehyde with pyrazole. A substoichiometric quantity of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium nitrate was used as the oxidant. The reaction was performed solvent-free and in the absence of a base, making it a clean, green approach. The mixture of aldehyde, pyrazole, and the oxidant was heated at 55 °C for 3 h, and then, the product was isolated in analytically pure form via extraction with no need for column chromatography.
Databáze:	Directory of Open Access Journals
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