Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Autor:	Veronika V. Zlobina, Alexey S. Kiryutin, Igor A. Nikovskiy, Oleg I. Artyushin, Vitaly P. Kozinenko, Alexander S. Peregudov, Alexandra V. Yurkovskaya, Valentin V. Novikov
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	heteroatomic nuclei hyperpolarization hyperpolarized probe magnetic resonance imaging NMR spectroscopy 31P nucleus Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 1, p 557 (2022)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms24010557
Popis:	Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.
Databáze:	Directory of Open Access Journals
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