| Autor: |
Allard S. Timmer, Niels Wolfhagen, Frank Pianka, Phillip Knebel, Christoph Justinger, Christos Stravodimos, Kosuke Ichida, Toshiki Rikiyama, József Baracs, András Vereczkei, Luca Gianotti, Marta Sandini, Jaime Ruiz-Tovar, Artur Marc-Hernández, Toru Nakamura, Marcel G. W. Dijkgraaf, Marja A. Boermeester, Stijn W. de Jonge |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Abdominal Wall Surgery, Vol 3 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2813-2092 |
| DOI: |
10.3389/jaws.2024.13337 |
| Popis: |
IntroductionWound closure with triclosan-coated sutures (TCS) appears to reduce the risk of surgical site infection (SSI). Because there is a strong association between postoperative SSI and the development of acute abdominal wall dehiscence (AWD) after laparotomy, we hypothesized that the use of TCS for wound closure after laparotomy may also reduce the risk of AWD.MethodsThe MEDLINE, Embase, and CENTRAL databases were searched from their inception to 01 November 2022. Randomized trials that compared the use of TCS with identical but uncoated sutures for fascial closure were eligible if they could provide individual participant data (IPD) on AWD. From these trials, we only included in the analysis those subjects who underwent open abdominal surgery. The primary outcome was the incidence of AWD within 30 days postoperatively, requiring emergency reoperation. The certainty of evidence was assessed using the GRADE methodology (PROSPERO: CRD42019121173.ResultsWe identified twelve eligible trials. Eight studies shared IPD. The incidence of AWD within 30 days after surgery was 27/1,565 (1.7%) in the TCS group vs. 40/1,430 (2.8%) in the control group (Relative Risk: 0.70 [95% confidence interval (CI) 0.44–1.11, I2 = 0%, τ2 = 0.00]). The certainty of evidence was moderate after downgrading for imprecision. The incidence of incisional SSI was 163/1,576 (10.3%) vs. 198/1,439 (13.8%), RR 0.80 (95% CI 0.67–0.97).ConclusionWe found no conclusive evidence to support the use of triclosan-coated sutures for the prevention of acute abdominal wall dehiscence after laparotomy. In these selected studies, a significant reduction in incisional SSI was observed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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